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Table 1 LncRNAs implicated in EMT, invasion, migration and metastasis of HNC

From: Long non-coding RNA implicated in the invasion and metastasis of head and neck cancer: possible function and mechanisms

LncRNA Description Cancer type Expression changes in cancer Correlation with tumor metastasis Functions in HNC Known molecular mechanisms Ref.
AFAP1-AS1 Actin filament associated protein 1 antisense RNA1 NPC up positive ↑invasion, migration, metastasis Translational control/ regulation of actin filament integrity [69]
CCAT1 Colon cancer-associated transcript-1 LSCC up ↑invasion miRNA sponge/transcriptional regulation [92]
CCAT1 Colon cancer-associated transcript-1 LSCC up ↑invasion, migration, EMT [91]
ENST00000470135 ENST00000470135 NPC up positive ↑invasion, migration [73]
FOXCUT FOXC1 promoter upstream transcript NPC up ↑migration mRNA stability modulation [20]
FOXCUT FOXC1 promoter upstream transcript OSCC up ↑migration mRNA stability modulation [84]
GAS5 Growth Arrest-specific Transcript 5 TC down negative [83]
H19 H19 LSCC up ↑invasion, migration Chromatin modification [97]
HIT000218960 HIT000218960 PTC up positive ↑invasion, migration Transcriptional regulation [70]
HNF1A-AS Hepatocyte nuclear factor 1A antisense RNA NPC up ↑EMT, migration [107]
HOTAIR Homeobox transcript antisense RNA HNSCC up ↑invasion, migration miRNA sponge/translational control [47]
HOTAIR Homeobox transcript antisense RNA OSCC up positive ↑invasion, migration Chromatin modification [19]
HOTAIR Homeobox transcript antisense RNA NPC up positive ↑invasion, migration [48]
HOTAIR Homeobox transcript antisense RNA LSCC up ↑invasion Chromatin modification [46]
HOTTIP HOXA transcript at the distal tip TSCC up positive [76]
KCTD6–3 KCTD6–3 HNSCC down ↓migration, EMT [108]
LCE5A-1 LCE5A-1 HNSCC down ↓migration, EMT [108]
LINC00152 Long intergenic non-coding RNA 152 TSCC up positive [77]
LINC00312 Long intergenic non-coding RNA 312 NPC down positive [74]
LINC00312 Long intergenic non-coding RNA 312 NPC up ↑invasion Translational control/upregulation of JNK2/AP-1/MMP1 pathways [75]
LINC00673 Long intergenic non-coding RNA 673 TSCC up ↑invasion, migration [105]
MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 OSCC up ↑invasion, migration Transcriptional regulation/NF-κB pathway activation [2]
MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 TSCC up ↑invasion, migration [35]
MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 TC up ↑invasion Chromatin modification [38]
MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 NPC up ↑invasion, migration, EMT [37]
MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 PTC up ↑EMT [39]
MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 TSCC up positive ↑EMT, migration, invasion Chromatin modification/Wnt/β-catenin pathway activation [34]
MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 TSCC up positive ↑migration, metastasis Via downregulation of small proline rich proteins [36]
NEAT1 Nuclear enrich abundant transcript 1 TC up ↑invasion, migration miRNA sponge [102]
NKILA NF-KappaB interacting lncRNA TSCC down negative ↓EMT, migration, invasion, metastasis Protein stability [81]
NONHSAT037832 NONHSAT037832 PTC down negative [82]
LncRNA-ROR Long Non-Coding RNA Reprogramming NPC up ↑invasion, migration,EMT [103]
RP11-169D4.1–001 RP11-169D4.1–001 LSCC up positive [78]
SOX21-AS1 SOX21 antisense RNA 1 OSCC down ↓invasion Chromatin modification [109]
TINCR Terminal differentiation-induced ncRNA HNSCC down ↓migration [110]
TUG1 Taurine upregulated gene 1 OSCC up positive ↑invasion Transcriptional regulation/Wnt/β-catenin pathway activation [66]
UCA1 Urothelial carcinoma-associated 1 HSCC up positive ↑invasion [58]
UCA1 Urothelial carcinoma-associated 1 OSCC up positive ↑migration,invasion Transcriptional regulation/Wnt/β-catenin pathway activation [49]
UCA1 Urothelial carcinoma-associated 1 TSCC up positive ↑migration [57]
  1. LncRNA long noncoding RNA, EMT epithelial-mesenchymal transition, HNC head and neck cancer, Ref. reference, NPC nasopharyngeal carcinoma, LSCC laryngeal squamous cell carcinoma, OSCC oral squamous cell carcinoma, TC thyroid carcinoma, PTC papillary thyroid carcinoma, HNSCC head and neck squamous cell carcinoma, TSCC tongue squamous cell carcinoma, HSCC hypopharyngeal squamous cell carcinoma