Table 2 Similarities and differences between MicroRNA nuclear and cytoplasmic functions
From: Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer
| Â | Cytoplasmic | Nuclear |
|---|---|---|
Regulation Level | Post-transcriptional | Post-transcriptional or Transcriptional |
Target | mRNA | Non-coding RNA, pri-miRNA, promoter, enhancer |
Mechanism | RNA-RNA hybrid | RNA-RNA hybrid, RNA-DNA hybrid, RNA-DNA triplex |
Effect | Silencing | Activation or Silencing |