From: New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications
Targets | miRNAs | Expression in tumor cells | Ref |
---|---|---|---|
VEGF | miR-20, miR-29b, miR-93, miR-126, miR-190, miR-195, miR-200, miR-203, miR-497, miR-503, miR-638, miR-27b, miR-128 | down | [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42] |
VEGF inducers | |||
 HIF-1 | miR-22, miR-107, miR-519c | down | |
 HIF-2 | miR-145 | down | [46] |
 PI3K/AKT pathway | miR-26a, miR-145 | down | |
 mTOR pathway | miR-18a, miR-128, miR-145, miR-218 | down | |
 IGF1R pathway | miR-126, miR-181b, miR-148a, miR-152 | down | |
VEGF upstream TFs | |||
 STAT3 | miR-874 | down | [56] |
 Bmi-1 | miR-16 | down | [57] |
 E2F3 | miR-34a | down | [58] |
 NF90 | miR-590-5p | down | [59] |
VEGF suppressor | |||
 PTEN | miR-21 | up | [60] |
 E-cadherin | miR-9 | up | [61] |
VEGF independent factors | |||
 FGF | miR-503 | down | [38] |
 HDGF | miR-214, miR-497 | down | |
 angiogenin | miR-409-3p | down | [64] |
 angiopoietin | miR-204 | down | [65] |
 MMPs | miR-9, miR-26b-5p, miR-98, miR-181a-5p | Down | |
 TSP-1 | miR-17-92 cluster, miR-182, miR-194, miR-467 | up |