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Table 1 MiRNAs involved in non-cell-autonomous regulation of tumor angiogenesis in tumor cells

From: New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

Targets

miRNAs

Expression in tumor cells

Ref

VEGF

miR-20, miR-29b, miR-93, miR-126, miR-190, miR-195, miR-200, miR-203, miR-497, miR-503, miR-638, miR-27b, miR-128

down

[21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42]

VEGF inducers

 HIF-1

miR-22, miR-107, miR-519c

down

[43,44,45]

 HIF-2

miR-145

down

[46]

 PI3K/AKT pathway

miR-26a, miR-145

down

[47, 48]

 mTOR pathway

miR-18a, miR-128, miR-145, miR-218

down

[49,50,51,52]

 IGF1R pathway

miR-126, miR-181b, miR-148a, miR-152

down

[53,54,55]

VEGF upstream TFs

 STAT3

miR-874

down

[56]

 Bmi-1

miR-16

down

[57]

 E2F3

miR-34a

down

[58]

 NF90

miR-590-5p

down

[59]

VEGF suppressor

 PTEN

miR-21

up

[60]

 E-cadherin

miR-9

up

[61]

VEGF independent factors

 FGF

miR-503

down

[38]

 HDGF

miR-214, miR-497

down

[62, 63]

 angiogenin

miR-409-3p

down

[64]

 angiopoietin

miR-204

down

[65]

 MMPs

miR-9, miR-26b-5p, miR-98, miR-181a-5p

Down

[66,67,68,69]

 TSP-1

miR-17-92 cluster, miR-182, miR-194, miR-467

up

[75,76,77,78]

  1. IGF1R Insulin-like growth factor I receptor, Bmi-1 B-cell-specific Moloney murine leukemia virus integration site 1, E2F3 E2F transcription factor 3, NF90 Nuclear factor 90, TSP-1 thrombospondin-1, HDGF hepatoma-derived growth factor