New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

Table 2 MiRNAs involved in cell-autonomous regulation of tumor angiogenesis in ECs

	miRNAs	Targets	Function	Ref
pro-angiogenesis	miR-132	p120RasGAP	promote ECs proliferation, tube formation	[86]
	miR-130a	GAX, HOXA5	promote ECs proliferation, migration, tube formation	[87]
	miR-146a	BRCA1	promote ECs proliferation, migration, tube formation	[84]
anti-angiogenesis	miR-128	VEGFR-2	inhibit ECs tube formation	[42]
	miR-497	VEGFR-2	induce ECs apoptosis	[82]
	miR-296	HGS	inhibit ECs tube formation	[83]
	miR-125b	VE-cadherin	inhibit ECs tube formation	[85]
	miR-34a	E2F3, SIRT1, survivin, CDK4	inhibit ECs proliferation, migration and tube formation	[58]
	miR-126	ADM	inhibit ECs migration and tube formation	[88]

HSG hepatocyte growth factor-regulated tyrosine kinase substrate, BRCA1 breast cancer 1, p120RasGAP Ras p21 protein activator 1, SIRT1 sirtuin 1, ADM adrenomedullin

ISSN: 1476-4598