From: New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications
miRNAs in EVs | Targets | Function | Ref |
---|---|---|---|
miR-494 | PTEN | promote ECs migration, tube formation | [95] |
miR-9 | SOCS5 | promote ECs migration, tube formation | [96] |
miR-1246 | PML | promote ECs proliferation, migration, tube formation | [97] |
miR-23a | PHD1, PHD2, ZO-1 | increase the number of tumor vessels, disrupt endothelial barriers | [98] |
miR-210 | Ephrin-A3 | Promote ECs tube formation | [99] |
miR-105 | ZO-1 | destroy tight junctions and integrity of vascular endothelial barriers | [102] |