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Table 1 Clinicopathological characteristic and piR-1245 expression in training and validation cohort

From: Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer

 

Training cohort

Validation cohort

Cases

Low

High

P c

Cases

Low

High

P c

Gender

 Male

91

45

46

0.9391

110

52

58

0.4255

 Female

104

52

52

 

79

42

37

 

Age

 ≤ 69a/66b

100

55

45

0.133

100

45

55

0.1687

 > 69a/66b

95

42

53

 

89

49

40

 

Tumor location

 Distal

150

82

68

*0.0123

121

55

66

0.1174

 Proximal

45

15

30

 

68

39

29

 

Histological type

 Well/moderate

175

90

85

0.0566

180

90

90

0.7456

 Poor

18

5

13

 

9

4

5

 

 Unknown

2

–

–

 

–

–

–

 

Pathological T category

 pT1-3

48

34

14

**0.0008

154

82

72

*0.0434

 pT4

147

63

84

 

35

12

23

 

Lymph node metastasis

 Negative

132

73

59

*0.025

85

53

32

**0.0025

 Positive

63

24

39

 

100

40

60

 

 Unknown

–

–

–

 

4

–

–

 

Distant metastasis

 Negative

187

96

91

*0.0319

143

80

63

**0.0027

 Positive

8

1

7

 

46

14

32

 

Stage

 I

29

21

8

**0.006

28

18

10

**0.0052

 II

99

51

48

 

53

33

20

 

 III

59

24

35

 

62

29

33

 

 IV

8

1

7

 

46

14

32

 
  1. Boldface P value denotes statistical significance  < 0.05
  2. aThe median age of training cohort is 69
  3. bThe median age of validation cohort is 66
  4. cPearson chi-squared testing was used - compare the correlation between piR-1245 expression and clinical variables. *P < 0.05;**P < 0.01