Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer

Table 2 Univariate and multivariate analysis for predictors of overall survival in training and validation cohort

	Univariate survival analysis			Multivariate survival analysis
	HR	95%CI	P	HR	95%CI	P
Training cohort
Gender(Male)	0.8471	0.4948-1.4500	0.545
Age (> 69)	1.9063	1.0970-3.3125	*0.0221
Tumor location (Proximal)	2.3263	1.3379-4.0449	**0.0028
Histological type (Poor)	2.1597	1.0165-4.5887	*0.0452	1.945	0.9003-4.2019	0.0905
T classification (pT4)	2.6736	1.2045-5.9346	*0.0156	2.1501	0.9431-4.9017	0.0687
Node involvement (Present)	1.6608	0.9700-2.8434	0.0644	1.3642	0.7813-2.3820	0.2748
Distant metastasis (Present)	4.8339	2.0511-11.3923	**0.0003	4.796	1.9696-11.6786	**0.0006
piR-1245 expression level (High)	2.387	1.3300-4.2838	**0.0035	1.965	1.0683-3.6144	*0.0298
Validation cohort
Gender(Male)	1.1471	0.7592-1.7334	0.5145
Age (> 69)	1.077	0.6065-1.9124	0.8002
Tumor location (Proximal)	0.7355	0.3972-1.3619	0.3284
Histological type (Poor)	3.7535	1.4754-9.5487	**0.0055	3.4914	1.2996 - 9.3799	*0.0132
T classification (pT4)	3.61	2.0014-6.5114	< 0.0001**	2.2202	1.1551 - 4.2673	*0.0167
Node involvement (Present)	1.921	1.2479-2.9573	**0.003	1.2908	0.5790 - 2.8776	0.5326
Distant metastasis (Present)	8.1136	4.4863-14.6739	< 0.0001**	4.7427	2.3622 - 9.5220	< 0.0001**
piR-1245 expression level (High)	3.208	1.6989-6.0578	**0.0003	2.9347	1.4584 - 5.9057	**0.0025

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