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Fig. 1 | Molecular Cancer

Fig. 1

From: Targeting Gas6/TAM in cancer cells and tumor microenvironment

Fig. 1

Roles of Gas6/TAM in cancer cells and the tumour microenvironment. Role of Gas6/TAM in cancer cells: Gas6 binds to TAM receptors in cancer cells and promotes their proliferation and migration and inhibits their apoptosis. Role of Gas6/TAM in the tumour microenvironment: Tumours can instruct intratumoral macrophages to overexpress and secrete Gas6 by secreting IL-10 and M-CSF into the microenvironment. Gas6 binds to TAM receptors on NK cells and inhibits their anti-tumour immune effect. Additionally, Gas6 can bind to TAM receptors on VSMCs and promote their proliferation and angiogenesis. Gas6, growth arrest-specific gene 6; IL, interleukin; M-CSF, macrophage colony-stimulating factor; NK, natural killer; VSMC, vascular smooth muscle cell

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