Fig. 3From: Targeting few to help hundreds: JAK, MAPK and ROCK pathways as druggable targets in atypical chronic myeloid leukemiaFasudil treatment for Morganalow leukemic cells. A diminished Morgana expression induces ROCK hyperactivation. ROCK plays a key role in multiple cell signaling processes, inducing proliferation and survival in myeloid cells. ROCK inhibition, through fasudil, results in increased apoptosis of leukemic cellsBack to article page