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Fig. 4 | Molecular Cancer

Fig. 4

From: Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells

Fig. 4

TKIs’ potential mechanism to reverse MDR. TKIs inhibit ABC transporter in manner of: (i) directly inhibiting the function of ABC transporter through blocking the ATP-binding site or changing the single nucleotide polymorphisms (SNPs) (ii) down-regulating the expression of ABC transporter and consequently influencing its normal function. Which increases intracellular drug concentration and results in reversal of MDR

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