Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells

Table 1 The characteristics of 4 generations of ABC transporter modulators

Generation	Representative	In vitro	In vivo	PK	Down-regulate ABC transporter
1st	verapamil, cyclosporin A, tamoxifen	+	–	+	–
2nd	PSC833, S97882, VX-710	+	+	+	–
3rd	GF120918, XR9576, R101933, LY335979	+	+	–	–
4th	neochamaejasmin B, curcumin	+	+	–	+

“+” stands for positive effective; “-” stands for ineffective; “PK” stands for pharmacokinetics

ISSN: 1476-4598