Skip to main content


Fig. 2 | Molecular Cancer

Fig. 2

From: Role and targeting of anaplastic lymphoma kinase in cancer

Fig. 2

ALK signaling pathway. ALK activates multiple pathways, including phospholipase C γ, Janus kinase (JAK)-signal transducer and activator of transcription (STAT), PI3K-AKT, mTOR, sonic hedgehog (SMO and GLI), and MAPK signaling cascades, which affect cell growth, transformation and anti-apoptotic signaling. Receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) inactivates ALK through de-phosphorylation

Back to article page