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Fig. 2 | Molecular Cancer

Fig. 2

From: Disruption of ETV6 leads to TWIST1-dependent progression and resistance to epidermal growth factor receptor tyrosine kinase inhibitors in prostate cancer

Fig. 2

ETV6 is inversely correlated with TWIST1 in human prostate cancer. (a) Pearson correlation analysis between ETV6 and epithelial-to-mesenchymal transition (EMT) transcription factors, using the Taylor and TCGA clinical prostate cancer datasets. (b, c) Correlation profiles between TWIST1 and ETV6 in the Taylor (b) and TCGA (c) clinical prostate cancer datasets. (d, e) Mean mRNA analysis of ETV6 (D) or TWIST1 (e) in normal prostate tissues (Nor., n = 28), and primary (Pri., n = 98) and metastatic (Met., n = 13) prostate cancer of the Taylor prostate cancer dataset. (f) Monitoring ETV6 and TWIST1 mRNAs in a panel of human prostate cancer cells. Gene expression was normalized to GAPDH. (g) Measurement of ETV6 and TWIST1 protein in prostate cancer cells by a Western blot assay. (h) Quantification of mRNA in prostate cancer tissue samples from the Taipei Medical University Joint human biological database. Left panel: Association analysis between ETV6 and TWIST1 in samples with two relative TWIST1 levels (H, high; L, low, n = 11 each group). Right panel: Pearson correlation analysis between ETV6 and TWIST1 mRNA in the same set of human prostate samples. Significance was determined by the Gaussian population (Pearson) and a two-tailed test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

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