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Fig. 3 | Molecular Cancer

Fig. 3

From: Novel targeted therapies and immunotherapy for advanced thyroid cancers

Fig. 3

Tumor immune escape phase: The increased expression of checkpoint inhibitors on T cells surface and their corresponding ligands on tumor cells lead to remarkable inhibition of host immune response. Presence of regulatory T cells (Treg) and M2 phenotype TAM (tumor associated macrophages) in tumor microenvironment contribute to tumor progression through T cell suppression by the first and pro-tumor IL-10 secretion by the second

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