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Fig. 4 | Molecular Cancer

Fig. 4

From: Novel targeted therapies and immunotherapy for advanced thyroid cancers

Fig. 4

Immune checkpoints and their proposed mechanism of action in T cells: Several immune checkpoints are overexpressed on T cell surface in thyroid tumor microenvironment and their corresponding ligands on tumor cells or immature dendritic cells. Interaction of receptors and ligands lead to inhibition of the AKT pathway inside T cells and subsequently inhibition of T cell proliferation and division

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