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Fig. 3 | Molecular Cancer

Fig. 3

From: CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer

Fig. 3

a. The table displays the number and type of cell injected, the number of mice and treatment for each group used for the xenograph experiment. b. Schematic representation of xenograph experiment time line. c. Representative picture of the ovarian peritoneal carcinosis seen after sacrifice of the mice (left picture). Representative picture of the bioluminescence signal (right picture). d. Explanation of the peritoneal carcinosis scoring. e. The histogram represent the mean of PCI score observed in each mouse of sacrifice. f. Tumors were snap-frozen after isolation and then were sectioned to 10 μm for immuno-staining. Slides were stained with Anti Human IL6-R and IL-6 antibodies and Immunofluorescence images were acquired in confocal microscopy. Scale: 100 μm. g-h. RNA was extracted from isolated tumor of each group. The relative quantification of IL-6 (g) and IL-6R (h) gene was performed by RT-PCR. The histogram represents ratios between each condition groups and the control group of their 2–ΔΔCp real-time PCR values. p < 0.05 (*), p < 0.01 (**) or p < 0.001 (***)

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