Name of the receptor (HGNC Official Name) | Gene Symbol | Gene Locus | Ligand | Structural Feature of the Class | Primary Localization | Alternate Localization | Function | ||
---|---|---|---|---|---|---|---|---|---|
Domain | Motif | ||||||||
Epidermal growth factor receptor | EGFR | 7p11.2 | EGF | Three FU, one REC, one TM, and one TYK domain | One SP | Plasma Membrane | Endosome, Clathrin-coated vesicle, Cytoplasm | Stimulate proliferation of different cell types | |
Insulin like growth factor I receptor | IGF1R | 15q26.3 | IGF1/IGF2 | One FU, one TM, one TYK, two REC, three FN3, and one TM domain | One SP | Plasma membrane | Â | Regulation of cell growth and survival | |
MET proto-oncogene | MET | 7q31 | HGF | One TYK domain, One PSI, One SEMA, four IPT domains | One SP | Plasma Membrane | Cytoplasm | In biological processes like cellular proliferation, motility, migration, & invasion | |
Vascular endothelial growth factor receptor | FMS related tyrosine kinase 1 | FLT1 | 13q12.3 | VEGF | Five Ig_LIKE domains, two IGC2 domains, one TM domain, and one TYK domain | One SP | Plasma Membrane | Extracellular | Transmembrane receptor protein tyrosine kinase activity cell communication, signal transduction, and stimulate angiogenesis |
Kinase insert domain receptor | KDR | 4q12 | VEGF | Cytoplasmic | |||||
Platelet derived growth factor receptor | PDGFRA | 4q12 | PDGF | Three Ig LIKE, one IGC2, one TM, and one TYK domain | One SP | Plasma membrane | Extracellular | Growth, differentiation and cell death controls | |
PDGFRB | 5q32 | ||||||||
ALK | ALK | 2p23.2-p23.1 | Heparin (an activating ligand) | One TM, one TYK domain, one LDLA, & one MAM | One SP, two NPXY | Plasma membrane | Cell surface | Embryonic brain development, Important role in the genesis and differentiation of the nervous system | |
Protein tyrosine kinase 7 | PTK7 | 6p21.1 | No known ligand (Context-dependent signaling switch for the Wnt pathways Wnt) | Five IGC2, two Ig LIKE, a TM, & a TYK domain | One SP | Plasma Membrane | Cytoplasmic expression | Cell adhesion, migration, polarity, proliferation, actin cytoskeletal reorganization and apoptosis |