Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma

Manoj Kumar Kashyap; Omar Abdel-Rahman

doi:10.1186/s12943-018-0790-4

Molecular Cancer

Table 1 Biological Characteristics of Some of the Receptor Tyrosine Kinases Reported in Esophageal Squamous Cell Carcinoma

From: Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma

Name of the receptor (HGNC Official Name)		Gene Symbol	Gene Locus	Ligand	Structural Feature of the Class		Primary Localization	Alternate Localization	Function
Name of the receptor (HGNC Official Name)		Gene Symbol	Gene Locus	Ligand	Domain	Motif	Primary Localization	Alternate Localization	Function
Epidermal growth factor receptor		EGFR	7p11.2	EGF	Three FU, one REC, one TM, and one TYK domain	One SP	Plasma Membrane	Endosome, Clathrin-coated vesicle, Cytoplasm	Stimulate proliferation of different cell types
Insulin like growth factor I receptor		IGF1R	15q26.3	IGF1/IGF2	One FU, one TM, one TYK, two REC, three FN3, and one TM domain	One SP	Plasma membrane		Regulation of cell growth and survival
MET proto-oncogene		MET	7q31	HGF	One TYK domain, One PSI, One SEMA, four IPT domains	One SP	Plasma Membrane	Cytoplasm	In biological processes like cellular proliferation, motility, migration, & invasion
Vascular endothelial growth factor receptor	FMS related tyrosine kinase 1	FLT1	13q12.3	VEGF	Five Ig_LIKE domains, two IGC2 domains, one TM domain, and one TYK domain	One SP	Plasma Membrane	Extracellular	Transmembrane receptor protein tyrosine kinase activity cell communication, signal transduction, and stimulate angiogenesis
Vascular endothelial growth factor receptor	Kinase insert domain receptor	KDR	4q12	VEGF		One SP	Plasma Membrane	Cytoplasmic
Platelet derived growth factor receptor		PDGFRA	4q12	PDGF	Three Ig LIKE, one IGC2, one TM, and one TYK domain	One SP	Plasma membrane	Extracellular	Growth, differentiation and cell death controls
Platelet derived growth factor receptor		PDGFRB	5q32	PDGF	Three Ig LIKE, one IGC2, one TM, and one TYK domain	One SP	Plasma membrane	Extracellular	Growth, differentiation and cell death controls
ALK		ALK	2p23.2-p23.1	Heparin (an activating ligand)	One TM, one TYK domain, one LDLA, & one MAM	One SP, two NPXY	Plasma membrane	Cell surface	Embryonic brain development, Important role in the genesis and differentiation of the nervous system
Protein tyrosine kinase 7		PTK7	6p21.1	No known ligand (Context-dependent signaling switch for the Wnt pathways Wnt)	Five IGC2, two Ig LIKE, a TM, & a TYK domain	One SP	Plasma Membrane	Cytoplasmic expression	Cell adhesion, migration, polarity, proliferation, actin cytoskeletal reorganization and apoptosis

FU Furin-like repeats, REC cheY-homologous receiver domain, TM Tramsmembrane domain, SP Signal peptide motif, NPXY Asn-Pro-X-Tyr, TYK Tyrosine kinase domain, LDLA LDL receptors, the class A, KRINGLE Kringle Domain, FZ Frizzled domain
Note: primary and secondary localization of the receptor tyrosine kinases are either based on the information annotated in the Human Protein reference Database (HPRD, http: hprd.org) or the human protein atlas (HPA, https://www.proteinatlas.org)

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