Epidermal growth factor receptor
|
EGFR
|
7p11.2
|
EGF
|
Three FU, one REC, one TM, and one TYK domain
|
One SP
|
Plasma Membrane
|
Endosome, Clathrin-coated vesicle, Cytoplasm
|
Stimulate proliferation of different cell types
|
Insulin like growth factor I receptor
|
IGF1R
|
15q26.3
|
IGF1/IGF2
|
One FU, one TM, one TYK, two REC, three FN3, and one TM domain
|
One SP
|
Plasma membrane
| |
Regulation of cell growth and survival
|
MET proto-oncogene
|
MET
|
7q31
|
HGF
|
One TYK domain, One PSI, One SEMA, four IPT domains
|
One SP
|
Plasma Membrane
|
Cytoplasm
|
In biological processes like cellular proliferation, motility, migration, & invasion
|
Vascular endothelial growth factor receptor
|
FMS related tyrosine kinase 1
|
FLT1
|
13q12.3
|
VEGF
|
Five Ig_LIKE domains, two IGC2 domains, one TM domain, and one TYK domain
|
One SP
|
Plasma Membrane
|
Extracellular
|
Transmembrane receptor protein tyrosine kinase activity cell communication, signal transduction, and stimulate angiogenesis
|
Kinase insert domain receptor
|
KDR
|
4q12
|
VEGF
|
Cytoplasmic
|
Platelet derived growth factor receptor
|
PDGFRA
|
4q12
|
PDGF
|
Three Ig LIKE, one IGC2, one TM, and one TYK domain
|
One SP
|
Plasma membrane
|
Extracellular
|
Growth, differentiation and cell death controls
|
PDGFRB
|
5q32
|
ALK
|
ALK
|
2p23.2-p23.1
|
Heparin (an activating ligand)
|
One TM, one TYK domain, one LDLA, & one MAM
|
One SP, two NPXY
|
Plasma membrane
|
Cell surface
|
Embryonic brain development, Important role in the genesis and differentiation of the nervous system
|
Protein tyrosine kinase 7
|
PTK7
|
6p21.1
|
No known ligand (Context-dependent signaling switch for the Wnt pathways Wnt)
|
Five IGC2, two Ig LIKE, a TM, & a TYK domain
|
One SP
|
Plasma Membrane
|
Cytoplasmic expression
|
Cell adhesion, migration, polarity, proliferation, actin cytoskeletal reorganization and apoptosis
|