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Table 1 Prognostic significance of PKM2 in human cancers

From: Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

Cancer Detection Gene Expression Prognosis Ref.
Mesothelioma qRT-PCR PKM2, ARHGDIA Increased Poor [58]
  TM4SF1, COBLL1  
Chordoma IHC PKM2, ENO1, gp96 increased poor [59]
Gastric cancer q-RT-PCR/IHC PKM2 increased poor [60]
Gallbladder cancer IHC PKM2, ACVR 1C increased poor [61]
  GAPDHS, TYRP1  
Melanoma IHC PKM2, GAPDH increased poor [62]
Ovarian cancer q-RT-PCR/IHC PKM2, GAPDH, ATP5B increased poor [63]
Tongue cancer IHC PKM2, LDH5 increased poor [64]
Esophageal cancer IHC/WB PKM2, HK1, PFKB increased poor [65]
Hepatoma IHC PKM2 increased poor [66]
Hepatoma IHC PKM2, TRIM35 increased poor [67]
Hepatoma IHC PKM2, Bim increased poor [68]
Cervical cancer IHC PKM2 increased poor [69]
Oral cancer IHC PKM2 increased poor [70]
Pancreatic cancer IHC PKM2, HK2 increased poor [71]
Breast cancer IHC PKM2, VEGF-C increased poor [72]
Pancreatic cancer IHC PKM2 increased poor [73]
Gastric cancer IHC PKM2, HK1 increased poor [74]
Cholangiocarcinoma IHC PKM2 increased poor [75]
Colorectal cancer IHC PKM2 increased poor [76]
Pancreatic cancer IHC PKM2, LDHA increased poor [77]
Gallbladder cancer IHC PKM2 increased poor [78]
Osteosarcoma IHC PKM2 increased poor [79]
Gastric cancer IHC PKM2 increased poor [80]
Ovarian cancer IHC PKM2 increased poor [81]
  1. Abbreviation: q-RT-PCR quantitative reverse-transcriptase polymerase chain reaction, ARHGDI Rho GDP dissociation inhibitor alpha, TM4SF1 transmembrane 4 L six family member 1, COBLL1 Cordon-Bleu WH2 repeat protein like 1, ENO1 enolase-1, gp96 heat shock protein 90 beta family member 1, ACVR 1C activin A receptor type 1C, GAPDH glyceraldehyde-3-phosphate dehydrogenase, GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic, TYRP1 tyrosinase related protein 1, ATP5B mitochondrial ATP synthase beta subunit, LDH5 lactate dehydrogenase 5, HK1 hexokinase 1, PFKB phosphofructokinase-2, TRIM35 Tripartite motif containing 35, HK2 hexokinase 2, VEGF-C vascular endothelial growth factor C