Table 1: Role of miRNAs and lncRNAs in the regulation of RTK signaling
Serial No. | Molecule | miRNA/lncRNA | Target RTK pathway | Pathological function |
|---|---|---|---|---|
1 | MiR-26a/b | miRNA | EGFR (ErbB2) | Regulates expression of ErbB2; competes with HuR for binding to its 3’UTR in tamoxifen-resistant ER+ breast cancer [95] |
2 | MiR-34a | miRNA | EGFR (ErbB2) | Downregulates expression of ErbB2 [96] |
3 | MiR-155 | miRNA | EGFR (ErbB2) | Downregulates HDAC2, a transcriptional activator of ErbB2; binds directly to a regulatory sequence over the coding region of ErbB2 [97] |
4 | MiR-24 | miRNA | EGFR | Regulates levels of phospho-EGFR by targeting phosphatases, PTPN9 and PTPRF [98] |
5 | MiR206 | miRNA | EGFR, MET | Downregulates EGFR and c-MET [99] |
6 | H19/miR675 | lncRNA/daughter miRNA | EGFR, MET | Stabilizes EGFR and c-MET by targeting c-Cbl and Cbl-b [100] |
7 | CYTOR | lncRNA | EGFR | Regulates expression of EGFR pathway specific genes [101] |
8 | BCAR4 | lncRNA | ErbB2/3 | BCAR4 enhances ErbB2/3 activity in tamoxifen-resistant breast cancer [102] |