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Fig. 1 | Molecular Cancer

Fig. 1

From: The relevance of tyrosine kinase inhibitors for global metabolic pathways in cancer

Fig. 1

TKI-induced regulation of glycolytic pathway. Highlighted in bold are proteins and metabolites (blue) together with glycolytic regulators (red) that were shown to be affected by the inhibition of TKs. Abbreviations: GLUT1/3glucose transporter 1/3; HK1/2/3hexokinase 1/2/3; TIGARTP53-inducible glycolysis and apoptosis regulator; Pphosphate; BPbisphosphate; PPPpentose phosphate pathway; GPIglucose-6-phosphate isomerase; PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; PFK6- phosphofructokinase(three isoforms – muscle (PFKM), liver (PFKL) and platelet (PFKP)); FBP1/2fructose-bisphosphatase 1/2; ALDOA/B/Caldolase A/B/C; TPI1—triosephosphate isomerase; PGAM1/2—phosphoglycerate mutase 1/2; ENO1/2/3—enolase 1/2/3; PKM2—pyruvate kinase isozyme M2; PKLR—Pyruvate kinase isozymes L/R; LDHA/B/C—lactate dehydrogenase A/B/C; TCA cycletricarboxylic acid cycle

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