Fig. 1From: Advances in studies of tyrosine kinase inhibitors and their acquired resistanceCell signaling pathways induced by RTK. RTK can bind to ligands and phosphorylate tyrosine residues of target proteins and transmit information through PI3K/AKT/mTOR; RAS/RAF/MEK/ERK; PLCγ/PKC and other signaling pathways to activate a series of biochemical reactions; or different information combined to cause a comprehensive cellular response, including cell proliferation, cell migration and tumor formationBack to article page