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Fig. 1 | Molecular Cancer

Fig. 1

From: Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

Fig. 1

Synthesis and screening of compounds 3a-f and 4a-d for anticancer activity. a Reagents and conditions: i) R2I, K2CO3, Dimethylformamide, 60 °C, 3 h, 51-56%; ii) 24a-e, Pd(PPh3)2Cl2, CuI, Triethylamine, Dimethylformamide, rt., 3 h, 40-72%. b Inhibitory effects of compounds 3a-f and 4a-d on the viability of A549 and MCF7 cells were evaluated by the MTT assay. The bars represent the means ± SD

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