Compd | linkage | R2 | R3 | % cells growth at 10 μM | |
---|---|---|---|---|---|
A549 | MCF-7 | ||||
3a | para | i-Pr | H | 34 | 27 |
3b | i-Pr | Cl | 16 | 53 | |
3c | i-Pr | F | 28 | 58 | |
3d | Et | H | 87 | 84 | |
3e | Et | Cl | 95 | 94 | |
3f | Et | F | 99 | 90 | |
4a | meta | i-Pr | H | 68 | 71 |
4b | i-Pr | OMe | 9.7 | 15 | |
4c | Et | H | 87 | 82 | |
4d | Et | OMe | 6.2 | 6.4 | |
Bosutinib | Â | Â | Â | 46 | 75 |
1b | Â | Â | Â | 98 | 92 |
23a | Â | Â | Â | 69 | 60 |