Skip to main content

Advertisement

Table 1 Structures of compound 3a-f and 4a-d and antiproliferative activity against cancer cell lines

From: Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

Compd linkage R2 R3 % cells growth at 10 μM
A549 MCF-7
3a para i-Pr H 34 27
3b i-Pr Cl 16 53
3c i-Pr F 28 58
3d Et H 87 84
3e Et Cl 95 94
3f Et F 99 90
4a meta i-Pr H 68 71
4b i-Pr OMe 9.7 15
4c Et H 87 82
4d Et OMe 6.2 6.4
Bosutinib     46 75
1b     98 92
23a     69 60