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Table 1 Structures of compound 3a-f and 4a-d and antiproliferative activity against cancer cell lines

From: Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

Compd

linkage

R2

R3

% cells growth at 10 μM

A549

MCF-7

3a

para

i-Pr

H

34

27

3b

i-Pr

Cl

16

53

3c

i-Pr

F

28

58

3d

Et

H

87

84

3e

Et

Cl

95

94

3f

Et

F

99

90

4a

meta

i-Pr

H

68

71

4b

i-Pr

OMe

9.7

15

4c

Et

H

87

82

4d

Et

OMe

6.2

6.4

Bosutinib

   

46

75

1b

   

98

92

23a

   

69

60