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Fig. 2 | Molecular Cancer

Fig. 2

From: Kinase-targeted cancer therapies: progress, challenges and future directions

Fig. 2

Categorization of different kinases implicated in human cancer. CTK: cytoplasmic tyrosine kinase, S/T Kinase: serine/threonine kinase, LK: lipid kinase, RTK: receptor tyrosine kinase. SK1: Sphingosine kinase 1, PI3K: phosphoinositide 3-kinase, PKCi: Protein kinase Ci, mTOR: mammalian target of rapamycin, CDKs: cyclin-dependent kinases, ATM: Ataxia telangiectasia mutated, Akt: protein kinase B, S6K: ribosomal protein S6 kinase, STK11/LKB1: Serine/threonine kinase 11 or liver kinase B1, PLKs: Polo-like kinases, b-Raf: B-Raf proto-oncogene, Aur A & B: Aurora Kinase A & B, c-SRC: Proto-oncogene tyrosine-protein kinase Src, c-YES: c-Yes proto-oncogene (pp62c-Yes), Abl: Abelson murine leukemia viral oncogene homolog 1, JAK-2: Janus kinase 2, RON: Recepteur d’Origine Nantais, FGFRs: Fibroblast growth factor receptors, c-Met: c-MET proto-oncogene, c-Ret: c-RET proto-oncogene, IGF-IR: Insulin-like growth factor 1 receptor, EGFR: Epidermal growth factor receptor, PDGFR-α: Platelet-derived growth factor receptor α, c-Kit: proto-oncogene c-Kit or Mast/stem cell growth factor receptor, Flt3,Flt-4: Fms-like tyrosine kinase 3, 4, PDGFR-β: Platelet-derived growth factor receptor β, ALK: Anaplastic lymphoma kinase, HER-2: human epidermal growth factor receptor-2

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