Table 1 Examples of oncogenic fusion proteins and their interactions with the IGF1R
From: Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway
Fusion protein | Chromosomes involved | Type of tumor | Interaction with IGF1R |
|---|---|---|---|
BCR-ABL | t(9;22) | Chronic myelogenous leukemia | IGF1R regulates the cell fate determination of BCR-ABL+ leukemia cells |
EWSR1-FLI1 | t(22;11) | Ewing sarcoma | An intact IGF1R is required for the oncogenic action of EWSR1-FLI1 |
TMPRSS2-ERG | t(21;22) | Prostate cancer | Overexpression of ERG leads to transactivation of the IGF1R gene |
MYB-NFIB | t(6;9) | Adenoid cystic carcinoma (salivary gland, others) | The fusion protein is regulated via IGF1R-stimulated AKT activation |
ETV6-NTRK3 | t(12;15) | Congenital fibrosarcoma, others | ETV6-NTRK3 forms a tripartite complex with phosphorylated IRS1 and IGF1R. This complex is critical for the oncogenic action of the chimera |
EWSR1-WT1 | t(11;22) | Desmoplastic small round cell tumor | The chimera transactivates the IGF1R gene |