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Table 1 Examples of oncogenic fusion proteins and their interactions with the IGF1R

From: Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway

Fusion protein Chromosomes involved Type of tumor Interaction with IGF1R
BCR-ABL t(9;22) Chronic myelogenous leukemia IGF1R regulates the cell fate determination of BCR-ABL+ leukemia cells
EWSR1-FLI1 t(22;11) Ewing sarcoma An intact IGF1R is required for the oncogenic action of EWSR1-FLI1
TMPRSS2-ERG t(21;22) Prostate cancer Overexpression of ERG leads to transactivation of the IGF1R gene
MYB-NFIB t(6;9) Adenoid cystic carcinoma (salivary gland, others) The fusion protein is regulated via IGF1R-stimulated AKT activation
ETV6-NTRK3 t(12;15) Congenital fibrosarcoma, others ETV6-NTRK3 forms a tripartite complex with phosphorylated IRS1 and IGF1R. This complex is critical for the oncogenic action of the chimera
EWSR1-WT1 t(11;22) Desmoplastic small round cell tumor The chimera transactivates the IGF1R gene