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Table 2 TMPRSS2-ERG target genes and signaling pathways

From: Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway

Targeted pathway Biological effect Reference
TGF-β1 Increased migration and invasiveness; reduced proliferation and accumulation in G1 phase; epithelial to mesenchymal transition. [98]
RUNX2 Destabilization of bone metabolism; effect on bone metastasis. [99]
Frizzled 4/WNT Changes in WNT signaling; effect on cell adhesion. [100]
NOTCH Effects on cell growth, survival and apoptosis. [101]