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Fig. 3 | Molecular Cancer

Fig. 3

From: The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC)

Fig. 3

Timeline of ALK Inhibitor Development in NSCLC. EML4-ALK discovery in NSCLC cancer led to the development of first-generation inhibitor crizotinib in 2007. Phase III clinical trials in 2013 and 2014 demonstrated that crizotinib was effective as first line therapy. Due to drug resistance to crizotinib, second-generation inhibitors ceritinib, alectinib and brigatinib were developed. Third-generation inhibitor loratinib is currently in phase III clinical trials. Figure was based on information in references [30, 34, 47, 48, 64, 65, 83]. Chemical structures for the following ALK TKI: crizotinib, ceritinib, alectinib, brigatinib, and lorlatinib were obtained from PubChem [100,101,102,103,104]

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