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Fig. 4 | Molecular Cancer

Fig. 4

From: The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC)

Fig. 4

Examples of known mutations in the tyrosine kinase domain of ALK and their influence on kinase activity and drug response. Schematic diagram of the tyrosine kinase domain of the ALK receptor with the location of known mutations. The mechanisms discussed in this review that promote kinase activity and resistance, if known, are indicated. Figure was based on information in references [49,50,51,52,53,54,55,56,57,58, 71, 72, 83]

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