Table 1 ALK inhibitors discussed and their activity against various ALK resistance mutations
| Â | Drug | ||||
|---|---|---|---|---|---|
ALK Resistance Mutations | Crizontinib | Ceritinib | Alectinib | Brigatinib | Lorlatinib |
L1196M | ♦ | • | • | • |  |
G1269A | ♦ | • | • | • |  |
S1206Y | ♦ | • |  | • |  |
V1180L | ♦ | • | ♦ | • |  |
G1202R | ♦ | ♦ | ♦ | ♦ | • |
C1156Y | ♦ | ♦ | • | • |  |
1151Tins | ♦ | ♦ |  | • |  |
F1174C/L | ♦ | ♦ | • | • |  |
L1152R/P | ♦ | ♦ (L1152R) |  | • |  |
L1198P | ♦ |  |  | • (L1198F) |  |
I1171N/T | ♦ | • | ♦ | • (I1171N) |  |
D1203N | ♦ |  |  | • |  |