Skip to main content

Table 2 Summary of lncRNAs regulate the Rho/ROCK signaling in cancer

From: LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis

LncRNAs Rho/Rho-associated protein Functions Refs
MALAT1 RhoA, ROCK1 and ROCK2 MALAT1 facilitates the metastasis of osteosarcoma though RhoA/ROCK pathway [103]
MALAT1 Cdc42 MALAT1 plays a role of Cdc42 ceRNA and induces migration by blocking miR-1 in breast cancer cells [104]
AFAP1-AS1 RhoA/Rac2 AFAP1-AS1 might promote tumor metastasis through regulation of tumor cell adhesion and mobility via RhoA/Rac2 signaling [7]
MEG3 Rac1 MEG3 is a novel suppressor of migration and metastasis by targeting Rac1 gene [107]
XLOC 010623 Rac1, RhoA and ROCK2 Tetrahedral DNA nanostructures (TDNs) suppressed the transcription of XLOC010623, and activated the TIAM1/Rac1 and RhoA/ROCK2 to promote cell migration [108]
SchLAH RhoA and Rac1 SchLAH suppressed migration of HCC cells through downregulating RhoA and Rac1 [110]
TDRG1 RhoC TDRG1 induced RhoC expression in epithelial ovarian carcinoma [111]
ABHD11-AS1 RhoC ABD11-AS1 can bind to RhoC directly in epithelial ovarian carcinoma [112]