Table 2 Summary of lncRNAs regulate the Rho/ROCK signaling in cancer
From: LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis
LncRNAs | Rho/Rho-associated protein | Functions | Refs |
|---|---|---|---|
MALAT1 | RhoA, ROCK1 and ROCK2 | MALAT1 facilitates the metastasis of osteosarcoma though RhoA/ROCK pathway | [103] |
MALAT1 | Cdc42 | MALAT1 plays a role of Cdc42 ceRNA and induces migration by blocking miR-1 in breast cancer cells | [104] |
AFAP1-AS1 | RhoA/Rac2 | AFAP1-AS1 might promote tumor metastasis through regulation of tumor cell adhesion and mobility via RhoA/Rac2 signaling | [7] |
MEG3 | Rac1 | MEG3 is a novel suppressor of migration and metastasis by targeting Rac1 gene | [107] |
XLOC 010623 | Rac1, RhoA and ROCK2 | Tetrahedral DNA nanostructures (TDNs) suppressed the transcription of XLOC010623, and activated the TIAM1/Rac1 and RhoA/ROCK2 to promote cell migration | [108] |
SchLAH | RhoA and Rac1 | SchLAH suppressed migration of HCC cells through downregulating RhoA and Rac1 | [110] |
TDRG1 | RhoC | TDRG1 induced RhoC expression in epithelial ovarian carcinoma | [111] |
ABHD11-AS1 | RhoC | ABD11-AS1 can bind to RhoC directly in epithelial ovarian carcinoma | [112] |