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Table 1 Circular RNAs function as ceRNAs to regulate and control human cancer progression

From: Circular RNAs function as ceRNAs to regulate and control human cancer progression

Circular RNA Biological functions miRNA Downstream pathways Tumor types The expression level References
CDR1as proliferation\invasion\ migration\biomarkers miR-7 EGFR, IGF-IR/PTEN/PI3K/AKT colon cancer HCC/GC up [23, 24]
cir-ITCH proliferation miR-7 /miR-214 ITCH(Wnt/β-catenin) lung cancer down [26]
circMTO1 proliferation\biomarkers miR-9 p21 HCC down [35]
hsa_circ_0013958 proliferation\biomarkers miR-134 cyclin D1 lung adenocarcinoma up [36]
circRNA_100290 proliferation miR-29b CDK6 OSCC up [37]
circTCF25 proliferation miR-103a-3p /miR-107 CDK6 bladder cancer up [38]
circPVT1 proliferation\biomarkers miR-125 E2F2 GC up [40]
hsa_circ_001569 proliferation miR-145 E2F5 colon cancer up [41]
circHIPK3 apoptosis miR-124 IL6R, DLX2 HCC up [42]
circUBAP2 apoptosis\biomarkers miR-143 Bcl-2 myeloma up [50]
hsa_circ_0001982 apoptosis\biomarkers miR-143 Bcl-2 breast cancer up [51]
circCCDC66 apoptosis miRNA-33b /miR-93 MYC colon cancer up [52]
circ_0009910 apoptosis\biomarkers miR-449a IL6R osteosarcoma up [53]
circGFRA1 apoptosis\biomarkers miR-34a GFRA1 TNBC up [55]
hsa_circ_0005986 Invasion/ migration miR-129-5p Notch1 mRNA HCC down [60]
circRNA-MYLK Invasion/ migration miR-29a VEGFA bladder cancer up [62]
circ-TTBK2 Invasion/ migration miR-217 HNF-1β glioma up [63]
circular RNA SRY Invasion/ migration miR-138 RhoC bile duct up [2]
circ-0016347 Invasion/ migration miR-214 caspase-1 osteosarcoma up [70]
hsa_circ_0005075 clinical diagnosis biomarkers    HCC up [72]