Circular RNAs function as ceRNAs to regulate and control human cancer progression

Table 1 Circular RNAs function as ceRNAs to regulate and control human cancer progression

Circular RNA	Biological functions	miRNA	Downstream pathways	Tumor types	The expression level	References
CDR1as	proliferation\invasion\ migration\biomarkers	miR-7	EGFR, IGF-IR/PTEN/PI3K/AKT	colon cancer HCC/GC	up	[23, 24]
cir-ITCH	proliferation	miR-7 /miR-214	ITCH(Wnt/β-catenin)	lung cancer	down	[26]
circMTO1	proliferation\biomarkers	miR-9	p21	HCC	down	[35]
hsa_circ_0013958	proliferation\biomarkers	miR-134	cyclin D1	lung adenocarcinoma	up	[36]
circRNA_100290	proliferation	miR-29b	CDK6	OSCC	up	[37]
circTCF25	proliferation	miR-103a-3p /miR-107	CDK6	bladder cancer	up	[38]
circPVT1	proliferation\biomarkers	miR-125	E2F2	GC	up	[40]
hsa_circ_001569	proliferation	miR-145	E2F5	colon cancer	up	[41]
circHIPK3	apoptosis	miR-124	IL6R, DLX2	HCC	up	[42]
circUBAP2	apoptosis\biomarkers	miR-143	Bcl-2	myeloma	up	[50]
hsa_circ_0001982	apoptosis\biomarkers	miR-143	Bcl-2	breast cancer	up	[51]
circCCDC66	apoptosis	miRNA-33b /miR-93	MYC	colon cancer	up	[52]
circ_0009910	apoptosis\biomarkers	miR-449a	IL6R	osteosarcoma	up	[53]
circGFRA1	apoptosis\biomarkers	miR-34a	GFRA1	TNBC	up	[55]
hsa_circ_0005986	Invasion/ migration	miR-129-5p	Notch1 mRNA	HCC	down	[60]
circRNA-MYLK	Invasion/ migration	miR-29a	VEGFA	bladder cancer	up	[62]
circ-TTBK2	Invasion/ migration	miR-217	HNF-1β	glioma	up	[63]
circular RNA SRY	Invasion/ migration	miR-138	RhoC	bile duct	up	[2]
circ-0016347	Invasion/ migration	miR-214	caspase-1	osteosarcoma	up	[70]
hsa_circ_0005075	clinical diagnosis biomarkers			HCC	up	[72]

ISSN: 1476-4598