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Fig. 3 | Molecular Cancer

Fig. 3

From: Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases

Fig. 3

MAP17 function in normal cells. MAP17 interaction with PDZK1 allows the assembly of a multimeric and variable complex responsible for cation/anion transport across the membrane. This complex potentiates the uptake of glucose by SGLT1/2 and the subsequent transport of glucose by GLUT1 from basolateral membrane to the bloodstream. Presence of MAP17-PDZK1 complexes in the trans-Golgi network allows cells to adapt to a change in ion transport requirements. The Notch pathway remains inactivated due to NUMB-NICD interaction, which labels NICD for ubiquitination and degradation

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