Fig. 3
From: Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases
MAP17 function in normal cells. MAP17 interaction with PDZK1 allows the assembly of a multimeric and variable complex responsible for cation/anion transport across the membrane. This complex potentiates the uptake of glucose by SGLT1/2 and the subsequent transport of glucose by GLUT1 from basolateral membrane to the bloodstream. Presence of MAP17-PDZK1 complexes in the trans-Golgi network allows cells to adapt to a change in ion transport requirements. The Notch pathway remains inactivated due to NUMB-NICD interaction, which labels NICD for ubiquitination and degradation