Fig. 3
From: RNA-Seq profiling of circular RNAs in human laryngeal squamous cell carcinomas
a Prediction of circRNA-miRNA associations. The cancer related miRNA was annotated by green nodes, and the number of cancer related miRNA to each circRNA (blue nodes) was counted in Additional file 1: Table S3. The common putative signaling pathway analysis for three candidate circRNAs were shown as below. b The venn map showed the nine common miRNAs regulated by three candidate cancer related circRNAs (hsa_circ:chr17:48268229–48,277,287, hsa_circ:chr 1:207103173–207,105,911 and hsa_circ:chr20:31876585–31,897,648). These nine miRNAs were shown in the right side of the venn map. c The putative signaling pathway was analyzed by KEGG using the targeted genes of these nine common miRNAs. d Downregulation of hsa_circ:chr20:31876585–31,897,648 in the LSCC tissues identified by Q-PCR. Ten paired LSCC tumor (T1-T10) and their adjunct tissues (C1-C10) were used to test the relative expression level of the candidate circRNA of hsa_circ:chr20:31876585–31,897,648. It was downregulated in eight LSCC samples compared with their adjunctive normal tissues (No Significant, NS; p < 0.05, *; p < 0.01, **)