Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non–small cell lung cancer cell proliferation by epigenetically repressing p21 expression

Table 2 Univariate and multivariate analysis of clinic pathologic factors for overall survival in 92 patients with NSCLC

Risk factors	Univariate analysis			multivariate analysis
Risk factors	HR^a	p value	95% CI	HR	p value	95% CI
AFAP1-AS1 expression	1.057	< 0.001**	1.039~ 1.075	1.046	< 0.001**	1.027~ 1.064
TNM stage (I/II, III/IV)	2.826	< 0.001**	1.688~ 4.730	2.618	0.001**	1.494~ 4.588
Histological grade (middle or low, high)	1.812	0.020*	1.100~ 2.986	1.697	0.048*	1.004~ 2.871
Tumor size (≤3 cm, > 3 cm)	1.561	0.086	0.939~ 2.595
Histological classification (SCC, AD or another)	1.187	0.487	0.731~ 1.928
Age (≤60, > 60)	0.941	0.806	0.580~ 1.527
N (negative, positive)	1.395	0.185	0.853~ 2.281
History of smoking (ever, never)	1.17	0.525	0.721~ 1.900
Sex (male, female)	1.236	0.39	0.762~ 2.006

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