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Fig. 7 | Molecular Cancer

Fig. 7

From: The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma

Fig. 7

LncRNA PTTG3P up-regulates PTTG1 expression in HCC. (a) The level of PTTG1 was detected in 46 HCC tumor tissues and paired non-tumor tissues by qRT-PCR. β-actin was used as a housekeeping gene. (b) The correlation between lncRNA PTTG3P and PTTG1 mRNA in 46 HCC tissues. The ΔCt values were subjected to spearman correlation analysis. (c) The protein level of PTTG1 was assessed in 8 HCC tissues and paired non-tumor tissues by western blot. β-tublin was used as a loading control. T, tumor tissues; N, non-tumor tissues. (d-f) Overexpression of PTTG3P induced the expression of PTTG1 mRNA (d) and protein (e, f) in HepG2 and Hep3B cells. Knockdown of PTTG3P blocked PTTG1 expression (d-f). β-tublin was used as a loading control. The experiments were performed in triplicate, *P < 0.05

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Molecular Cancer

ISSN: 1476-4598