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Fig. 8 | Molecular Cancer

Fig. 8

From: The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma

Fig. 8

A schematic model of lncRNA PTTG3P functions during tumor growth and metastasis cascade in HCC. LncRNA PTTG3P up-regulates PTTG1 and then activates PI3K/AKT signaling. Activation of PI3K/AKT signaling elevates the expression of C-myc and CyclinD1, then increasing the level of phosphorylated Rb, and finally promoting cell proliferation in HCC. On the other hand, activation of PI3K/AKT inactivates caspase3 and thus inhibits cell apoptosis, thereby accelerating tumor growth. In addition, PTTG3P promotes HCC cell migration and invasion by activating PI3K/AKT signaling, up-regulating Snail and Slug, down-regulating E-cadherin, then inducing EMT

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Molecular Cancer

ISSN: 1476-4598