Fig. 6
From: MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling
Effect of modulation of MASTL expression on tumor xenograft in vivo. (a-c) Flank tumor xenograft tumor development, after subcutaneous injection (n = 6 mice per group), was monitored for HCT116C, or HCT116MKD cells. Tumor volume and tumor weight of HCT116C and HCT116MKD cells after 4 weeks of inoculation in nude mice. (d) Tumors were evaluated for MASTL and β-catenin expression as well as markers of proliferation (Ki67) by immunohistochemistry; (e) Immunoblotting on tumors from 3 mice from each group (M1, M2 and M3) for Survivin, Bcl-xL and Cleaved PARP and normalized with tubulin as control. For graphs, data represent mean ± SD; **, P < 0.001; ***, P < 0.0001 versus control