Fig. 1

LncRNA NEAT1 is up-regulated in glioma tissues and cell lines. a The heat map of microarray analysis reflects the differentially expressed lncRNAs in tumor tissues. NEAT1 is one of the up-regulated lncRNAs in glioma tissue. N (high-grade tumor) = 7; N (low-grade tumor) = 7; N (normal) =5. b The volcano plot reflects the differentially expressed lncRNAs with fold change > 2 and P < 0.01. c The relative expression level of NEAT1 in normal tissue is lower compared with that in glioma tissue. NEAT1 expression level in low grade (stage I and stage II) glioma tissue is also lower than that in high grade (stage III and stage IV) glioma tissue. GAPDH is the internal control. N (high-grade tumor) = 7; N (low-grade tumor) = 7; N (normal) =5. ^** P < 0.01 and ^*** P < 0.001. d The relative NEAT1 expressions of glioma cell lines (U87, U251, SHG44, U-118MG) are higher than that in normal cell line HA, especially for U251 and U87. GAPDH is the internal control. ^** P < 0.01 compared with HA. e The relative expressions of miR-132 in glioma cell lines (U87, U251, SHG44, U-118MG) are lower than that in normal cell line HA. ^** P < 0.01 compared with HA. (F) The relative expressions of SOX2 in glioma cell lines (U87, U251, SHG44, U-118MG) are higher than that in normal cell line HA. ^** P < 0.01 compared with HA