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Fig. 5 | Molecular Cancer

Fig. 5

From: Knockdown of long non-coding RNA NEAT1 inhibits glioma cell migration and invasion via modulation of SOX2 targeted by miR-132

Fig. 5

NEAT1 elevates SOX2 expression through targeting miR-132 to promote glioma progression. a The relative mRNA expression of SOX2 in U251 and U87 cells decreases in miR-132 mimics group compared with NC, increases in miR-132 + NEAT1 group compared with miR-132 + pcDNA3.1, and almost remains the same between NC and miR-132 + NEAT1 groups. GAPDH is the internal control. * P < 0.05 and ** P < 0.01. b The protein expression of SOX2 in U251 and U87 cells decreases in miR-132 mimics group compared with NC, increases in miR-132 + NEAT1 group compared with miR-132 + pcDNA3.1, and almost remains the same between NC and miR-132 + NEAT1 groups. β-actin is the internal control. c The histogram of the western blot results. d-e The cell viability of U251 and U87 cells in miR-132 group is similar with that in miR-132 + pcDNA3.1 group, while that in miR-132 + NEAT1 group is similar with NC group. OD: optical density. * P < 0.05. f-g The invasion and migration of U251 and U87 cells decrease in miR-132 mimics group compared with NC, and remains similar with NC in miR-132 + NEAT1 group. Scale bar: 100 μm. Each experiment was performed in triplicate and measured for 3 times

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