Fig. 6
From: Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer
PDHX is inversely correlated with miR-27b in human normal breast and tumor tissues and is associated with improved patient outcomes. a Relative PDHX expression level in normal breast (n = 55) and breast tumor (n = 57) tissues. b Fold change in PDHX expression in tissues from panel a between normal and cancer tissue sample sets using the ∆∆CT method. c Relative PDHX expression level in normal breast compared breast cancer tissues divided by subtype: Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC). d Fold change of groups described in panel c. e Expression of PDHX across multiple breast cancer subtypes in the TCGA database. Number of samples in each category is indicated in parentheses. p = 0.03 for ductal breast carcinoma; p = 7.15E-4 for lobular breast carcinoma. f Representative images of PDHX western blots in tumor samples from five patients. g Quantitation of PDHX protein expression from normal (n = 10) and tumor (n = 10) patient samples