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Fig. 1 | Molecular Cancer

Fig. 1

From: RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer

Fig. 1

Copy number changes and mRNA expression of RASAL2 in CRC. a RASAL2, located on chromosome 1q, is one of the candidate genes showing increased copy numbers in the metastatic tumors in array-CGH. b RASAL2 mRNA expression was higher in CRC cell lines than in normal colons, and significantly higher in advanced stage cell lines than in early stage ones. c Upregulation of RASAL2 mRNA was found in primary tumors in local cohorts, GENT data and TCGA cohorts. d Higher RASAL2 mRNA expression was observed in primary tumors than their matched normal counterparts in our local cohort and GENT data. e RASAL2 mRNA expression was the highest in metastatic tumors, followed by primary tumors and normal colon mucosa in local cohort. f Out of 15 paired primary and metastatic tumor samples, 12 (80%) had a higher RASAL2 mRNA expression level in metastatic tumors than their primary counterparts. (*, P < 0.05; **, P < 0.01)

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