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Fig. 5 | Molecular Cancer

Fig. 5

From: RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer

Fig. 5

RASAL2 is involved in hippo pathway. a KEGG pathway enrichment analysis of RASAL2-regulated hippo pathway genes. b Western blot results showed that a higher level of LATS2 and phospho-YAP1 (Ser127) in siRASAL2 cells than that in the siControl group. c Western blot of LATS2, YAP1 and phospho-YAP1 (Ser127) expression upon LATS2 and RASAL2 double knockdown in CRC cells. Treatments with siControl, siRASAL2 and siLATS2 were shown in the upper panel. Phospho-YAP1 (Ser127) in LATS2 and RASAL2 double-knockdown group was high in siLATS2 group, but lower than that of the siRASAL2 group. d MTT assay showed siRNA-mediated double knockdown of RASAL2/LATS2 inhibited cell growth compared to the siLATS2 group in SW620 and Caco2 cells. e Colony formation assay showed reduced cell colonies in siRASAL2/siLATS2 double-knockdown cells, when compared to the siLATS2-treated cells. (*, P < 0.05; **, P < 0.01, Student’s t-test, n = 3 independent experiments)

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Molecular Cancer

ISSN: 1476-4598