Skip to main content
Fig. 2 | Molecular Cancer

Fig. 2

From: Epigenetics in ovarian cancer: premise, properties, and perspectives

Fig. 2

a Type A HAT families. AT: acetyltransferase domain; Zn: Zic finger domain; Bromo: bromodomain. GNAT domain includes three key motifs and these motifs in structure is in this order: D-A-B. Some of GNAT family members contain another conserved motif C that is located at the N-terminus of these proteins. b Topological diagram of the core GNAT fold. The highly conserved GNAT domain composed of 6–7 anti-parallel β-strands and 4 α-helices in the topology β1-α1-α2-β2-β3-β4-α3-β5-α4-β6-β7. Motifs A and B participate in acyl-CoA and acceptor substrate recognition and binding, and the feature of motif A is the “P-loop” that connect helix α3 and strand β4. Motifs C and D preserve the stability of proteins

Back to article page