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Fig. 4 | Molecular Cancer

Fig. 4

From: Epigenetics in ovarian cancer: premise, properties, and perspectives

Fig. 4

A series of targets of SIRT1, and its multiple pathways that contribute to ovarian cancer. SIRT1 deacetylases both histones and non-histones. SIRT1 could directly decrease the degree of acetylation of histone H1K26, H3K9, H3K14, and H4K16, and also indirectly regulate the methylation and acetylation of histone by interacting with other histone-modifying enzymes such as SUV39H1, P300, PCAF, and Tip60. The non-histone substrates of SIRT1 (transcriptional factors, DNA repair machinery elements, nuclear receptor genes, and signaling molecules) are critical in the initiation and progression of ovarian cancer

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