Table 1 Functional roles of FOXO3a pathway in different types of cancer
Cancer types | Key message(s) | Ref. |
|---|---|---|
Breast cancer | Dephosphorylation of FOXO3a induced by Aplysin suppresses tumor growth by inhibiting cell proliferation and promoting apoptosis in cancer cells. | [89] |
Prostate cancer | Deregulation of FOXO3a promotes prostate cancer progression in TRAMP mice. | [90] |
Acute myeloid leukemia | Dephosphorylation of FOXO3a induced by hypomethylating agents promote apoptosis by upregulation of BIM and PUMA expression. | [91] |
Colon cancer | Activation of FOXO3a by aldose reductase induces human colon cancer cell apoptosis by upregulating both DR5 and DR4. | [92] |
Lung cancer | Deregulation of FOXO3a promotes DNMT3B overexpression leading to tumor growth in lung cancer. | [93] |
Glioma | A high expression of FOXO3a is associated with glioblastoma progression and FOXO3a level independently indicates poor prognosis in Glioma patients. | [94] |
Thyroid cancer | Nuclear FOXO3a promotes cell cycle progression by transcriptional upregulation of cyclin A1 and accelerates proliferation of human ATC cells. | [95] |
Lung adenocarcinoma | FOXO3a gene inactivation occurs frequently in carcinogen-induced lung adenocarcinoma. | [96] |
Oral squamous cell carcinoma | Constitutively active form of FOXO3a induces significant G1-phase arrest and apoptosis in OSCC cells | [97] |
Neck cancer | Tumor patients with low FOXO3a expression have a poor prognosis compared with patients with high FOXO3a. | [98] |
Urothelial cancer | FOXO3a suppresses invasiveness of urothelial cancer through regulation of Twist1, YB-1 and E-cadherin. | [99] |
Osteosarcoma | Activation of FOXO3a by ionizing radiation induces cell apoptosis in osteosarcoma. | [100] |
Bladder cancer | Upregulation of FOXO3a by Nkx2.8 suppresses bladder cancer proliferation. | Â |
Gastric cancer | FOXO3a cooperates with RUNX3 to induce apoptosis by activating Bim in gastric cancer cells. | |
Neuroblastoma | Inactivation of FOXO3a by AKT is essential for neuroblastoma cell survival. | [102] |
Ovarian cancer | Inhibition of FOXO3a phosphorylation by BrMC upregulates Bim expression and leads to apoptosis in ovarian cancer cells. | [103] |