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Fig. 1 | Molecular Cancer

Fig. 1

From: FBXW7: a critical tumor suppressor of human cancers

Fig. 1

FBXW7 substrates and their conserved CDC4 phosphodegron. FBXW7 causes proteasome-mediated degradation of Notch1, c-Myc, cyclin E, Mcl-1, mTOR, and Jun. The amino acid sequence under each FBXW7 substrate indicates the conserved CDC4 phosphodegron (the phosphorylation residue “0” and “+ 4” positions are highlighted in red). The amino acid number and percentage indicate the hotspot mutations in human cancers. Mutation percentage data were retrieved from the COSMIC database

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