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Fig. 3 | Molecular Cancer

Fig. 3

From: FBXW7: a critical tumor suppressor of human cancers

Fig. 3

The distribution of FBXW7 mutations in the FBXW7 genome. The numbers of FBXW7 genetic alternations are retrieved from the COSMIC database. FBXW7 residues with a mutation number higher than 20 are highlighted in red and 3 FBXW7 hotspot mutations are labeled in blue. The bottom panel indicates FBXW7 protein domains (DD: dimerization domain amino acid 234–257, F-Box-like domain: amino acid 281–325 and WD40: amino acid 374–650)

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