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Fig. 1 | Molecular Cancer

Fig. 1

From: Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer

Fig. 1

The HER2 3’UTR promotes cell proliferation, colony formation, and tumor growth of breast cancer. a, b Breast cancer cells were transfected with the HER2 3’UTR, HER2 CDS, or the empty vector as a control. Cell proliferationwas assessed by CCK-8 assays at the indicated times (a), and colony formation was determined 7 d post transfection (b). All quantitative data were generated from a minimum of three replicates. c-f T47D or MCF7 cells stably transfected with the HER2 3’UTR or control vector were s.c. injected into female BALB/c-nude mice. Tumor diameters were measured every 3 d for 21 d (c, d). Weight of xenograft tumors at 30 d post inoculation (e). Representative immunostaining of Ki67 in T47D and MCF7 xenograft tumors (f). Green, Ki67; Blue, DAPI. Scale bar, 40 μm. The results are presented as means±SD from five mice. Data are representative of two independent experiments

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