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Fig. 6 | Molecular Cancer

Fig. 6

From: Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer

Fig. 6

Correlation between HER2 and HER3 levels in human breast cancer. a Correlation of HER2 and HER3 mRNA expression in 80 primary human breast tumors. b-d Correlation of HER2 and HER3 mRNA (B) HER2 mRNA and HER3 protein levels c, HER2 and HER3gene copy-number d in breast invasive carcinoma (TCGA). e Meta-analysis of gene expression microarray data. miR-125a/b and miR-146a targets predicted by TargetScan (TS) were analyzed. The Pearson score of coexpression with HER2 mRNA of miR-125a/b targets was compared to miR-146a targets or all genes; the number of genes in each group is shown. f Meta-analysis of gene interaction with HER2. Genes targeted by the same miRNAs are circled. g A schematic model of HER2-HER3 mRNA cross-talk in breast tumor development and trastuzumab resistance

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Molecular Cancer

ISSN: 1476-4598