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Fig. 1 | Molecular Cancer

Fig. 1

From: Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance

Fig. 1

Schematic and results of functional screening by sgRNA library and imatinib treatment. a Optical microscopic images of GIST-T1 cells treated with imatinib at day 4. b Structure of one vector lentiviralGeCKO system; c Schematic of imatinib-resistant GIST-T1 cells construction for high-throughput sequencing analysis; d Optical microscopic images of GIST-T1cells transfected with lentiviral sgRNA library and treated with imatinib. a-control, b-imatinib (40 μg/mL), c-transfection and imatinib (40 μg/mL)

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